Share on twitter
Share on linkedin

Av. rating

Share on twitter
Share on linkedin

How to deal with frustrating clinical mastitis?

In previous posts, we talked about the importance of knowing which pathogen is causing the bovine mastitis problem in your farm. Recent publications have shown an increase in the prevalence of Strep uberis in Europe. With the aim of knowing more about this pathogen, we share with you this publication of Doctor Volker Krömker to learn a little bit more of this pathogen.

Improved management on modern dairy farms decreases the relevance of subclinical mastitis. Clinical bovine mastitis is still a common and costly disease on dairy farms all over the world (IDF, 2005; Hogeveen et al., 2011). For several years, Streptococcus (Strep.) uberis has been the most important causative pathogen for clinical mastitis in many countries of the world (Fig. 1):

Fig. 1: Relative importance of Strep. uberis in bacteriologically positive clinical mastitis samples
(23 herds – Northwest Germany – n = 1739 cases)

Characteristics of Strep. uberis

On blood agar plates, Strep. uberis grows at 30 to 37°C. Colonies have a diameter of 1 to 2 mm after an incubation period of 24 to 48 hrs. Adding 0.1% aesculin to the medium enhances bacteria identification, as Strep. uberis and enterococci hydrolyse aesculin to glucose and aesculetin. Examination under ultraviolet light confirms this reaction.

Growth of Strep. uberis on blood agar plate. Source: V. Krömker

At present, many routine laboratories do not selectively differentiate Strep. uberis. Due to the rising cost pressure of high frequency analyses such as the microbiological investigation of quarter foremilk samples for bovine mastitis pathogens, identification is often limited to aesculin-hydrolysing streptococci, failing to differentiate Strep. uberis and enterococci or to identify aesculin-negative streptococci.

Several virulence factors are known for Strep. uberis. However, there are considerable differences in the exhibition of virulence factors between the various isolates. Biofilm formation is an important virulence factor that may cause recurrent or persistent mastitis in cattle by impairing the host immune defence and through the protection of antimicrobial substances. Nearly 100% of Strep. uberis strains are able to produce biofilms in vitro. Moreover, the enzymes produced by Strep. uberis seem to play a decisive role in the distribution of infections with this pathogen, which is able to impede the proper development of the mammary gland and to induce the formation of capsules in the tissue.


Strep. uberis is a ubiquitous microorganism, which colonizes animals as well as their environment. Environmental streptococci are responsible for about one third of all clinical mastitis in dairy cows cases. The pathogens enter the mammary gland via the teat canal. High pathogen levels in the animals’ environment increase the infection rates. Zadoks et al. (2005) found that Strep. uberis was present in 63% of environmental samples (i.e. earth, vegetable material and bedding), in 23% of faecal samples and 4% of milk samples. During summer (grazing season), contamination rates in bovine faeces are higher than in other seasons. Straw and other organic bedding material enhance the growth of Strep. uberis. If several cows in the same herd are infected, it is quite unlikely that all infections are caused by one identical Strep. uberis strain. Udder infections, which are caused by one dominant Strep. uberis strain, tend to persist on the farm for a longer period than udder infections caused by a multitude of strains. Most infections do not last a long time (16-46 days).

Risk factors

The cases of clinical mastitis in dairy cows caused by Strep. uberis are clearly associated with hygiene (cleanliness and dryness) in husbandry, feeding and machine milking. Strep. uberis infections of the mammary gland can occur during the dry period (evaluation of the new infection rate in the dry period) and often develop an acute course in the following lactation. Straw and other organic bedding materials promote the growth of Strep. uberis.


Recurrent mastitis

Udder quarters that have recovered from infection with Strep. uberis or other microorganisms exhibit an elevated risk of reinfection. Recent research has shown that Strep. uberis mastitis is often followed by recurrent Strep. uberis bovine mastitis in cases. Strain typing techniques have shown that most of these cases are new infections. Often misinterpreted as unsuccessful treatment, recurrent mastitis cases show that it is not the treatment that is the problem, but the fact that an infection increases the risk of new infections.

Adapted from Volker Krömker,

University of Applied Sciences and Arts, Hannover, Germany

How useful was this information for you?:

[Total: 0   Average: 0/5]

Leave a Reply

Your email address will not be published. Required fields are marked *

Related posts



    I have read and agree to the Privacy Policy and Basic information on Data Protection.


    Your opinion is very important to us, so we encourage you to contact our team of experts on Mastitis Vaccination to ask any questions or discuss any concerns you may have about mastitis.

      I have read and agree to the Privacy Policy and Basic information on Data Protection.

      Website for veterinarians

      The contents of this website are aimed exclusively at prescribing veterinarians. By clicking on Accept you state that you are a veterinary professional. In other case, please contact a veterinarian and click on Decline.

      Basic Personal Data Protection information:

      Controller: LABORATORIOS HIPRA, S.A.
      Purposes: Managing the contractual and/or business relationship with HIPRA, including sending news, promotions and invitations to events sponsored by HIPRA.
      Lawful basis: Performance of the contractual relationship and HIPRA’s legitimate Interest.
      Recipients: Third parties to which HIPRA has entrusted cloud computing, security, auditing, mailing, technical and computer support services, as well as companies in its group.
      Rights: Request access to and rectification or erasure of personal data and other rights as explained in the additional information. You can seeview the detailed additional information about data protection in our Privacy Policy.

      For further information, please check our detailed information on Data Protection.